Services

Occupational Exposure Assessment

Protecting workers begins with understanding real exposure. We assess workplace scenarios using measured or modelled data, integrating toxicological thresholds, use patterns, and task-specific factors. The result: defensible conclusions that balance realism with regulatory acceptance.

Key disciplines are:

• Generation of exposure data

  We collect exposure information via two coordinated channels. A targeted, questionnaire-driven intake invites companies to share existing monitoring results with essential context (tasks, SEG definitions, control measures, operating patterns). In parallel, we gather site-specific intelligence to understand real workflows, controls in use - pinpointing where new measurements add the most value.

  With this evidence, we select representative sites and co-design a pragmatic campaign: stratifying by similar exposure groups, process category, and controls; confirming feasibility in brief interviews; and agreeing on task-based or full-shift sampling, worker/shift counts, and needed replication to capture variability. All information is processed under strict GDPR compliance, minimizing identifiers and safeguarding data throughout.

• REACH Use Descriptions

  Content

• Exposure Scenario building

  Effective risk management starts with the well-defined exposure scenario. We develop use- and task-specific scenarios that reflect real operational conditions while meeting regulatory expectations. Each scenario integrates substance properties, process parameters, and control measures — a solid basis for realistic exposure and risk assessments.

Environmental Exposure Assessment

In context of the EU Plant Protection Products Regulation, EU Biocidal Products Regulation and REACH Regulation.

• Collection of information
• Development of exposure scenarios
• Estimation of environmental exposure concentration and risk characterisation for relevant protection targets
• Modelling applications & software
  • Current FOCUS models for estimating environmental concentrations (e.g. PEARL, PELMO, MACRO, PRZM, TOXSWA)
  • EUSES integrated in Chesar/Chesar Platform (for the estimation of environmental concentrations for protection targets of industrial chemicals)
  • Biocides (EUSES and Emission Scenario Documents)
• Model refinements
  • For Plant Protection Products:
  • Impact estimation based on potential future exposure models such as PERSAM or updates to existing models
  • Additional qualitative exposure estimations as required
  • Implementation of accepted risk mitigation measures based on specific zonal or country-specific guidance
  • Refinement of predicted environmental concentrations (PECs) based on existing or newly generated data
  • Use of EU-member-state-specific exposure models (e.g. EXPOSIT, EVA, FROGS, GeoPEARL)
  • Analysis of the temporal patterns of predicted environmental exposure for additional refinement over standard FOCUS approaches incl. our own tools
  • Probabilistic and GIS-based approaches for exposure predictions in close cooperation with the applicant and / or the competent authority
  • For Industrial Chemicals:
  • Release factor based on sector-specific information or OECD ESD
  • Site-specific measured data (monitoring campaign)
  • Regional assessment based on monitoring datasets (if available)
  • For Biocides:
  • Implementation of acceptable risk mitigation measures based on the guidance
  • Refinement of predicted environmental concentrations (PECs) based on existing or newly generated data
  • Additional qualitative exposure estimations as required
• Proposal for risk management/mitigation measures (RMMs)
• Documentation and communication
• Documentation and communication

Consumer Exposure Assessment

The REACH regulation requires companies to comprehensively understand and document the exposure pathways and specific conditions under which consumers can safely handle products or articles containing their substance. This involves conducting representative assessments that describe both the presence of the substance in mixtures or articles and its concentration levels. In addition, it is essential to provide a comprehensive description of the intended conditions of use, while the provision of personal protective equipment is not envisaged. In certain instances, a tiered approach, ranging from default generic values to refined, use-specific scenarios, is imperative to demonstrate safe use of a consumer product/article.

EBRC provides the following services for companies to meet their regulatory obligations.

• Collection of relevant product/ articles specific information
• Consideration of exposure potential per route for the respective consumer use/ article
• Development of exposure scenarios and defining conditions of use:
  • Using defaults in ECETOC TRA
  • Using published data and read-across from analogue substances
  • Using information from RIVM fact sheets
  • RAC opinions on metal compounds used by consumers or included in articles
  • EU risk assessment reports
• Estimation of consumer exposure concentration and risk characterisation for relevant routes
  • ECETOC TRA (1.Tier for inhalation, dermal and oral route)
  • ConsExpo
  • Using monitoring data (incl. analogous and published)
  • o Use of own models built on plausibility considerations and experience

Humans via the Environment Assessment

The “Humans via the Environment” assessment is required for hazardous substances when the annual tonnage exceeds 1,000t, or when it is over 100t per year and the substance is classified as STOT RE1, carcinogenic, mutagenic (any category), or reproductive toxicant (category 1A or 1B). The assessment will be performed at a local level—focusing on direct, site specific exposures—or at a regional level, which considers broader geographic areas.

In both approaches, human exposure through environmental media, specifically food, drinking water, and air, are quantified in order to demonstrate compliance with REACH safety requirements.

• Estimation of environmental exposure concentration (food, water and air) and risk characterisation for humans
• Modelling applications & software
  • EUSES integrated in Chesar/Chesar Platform (for the estimation of environmental concentrations for protection targets of industrial chemicals)
• Model refinements
  • Release factor based on sector-specific information or OECD ESD
  • Site-specific measured data (monitoring campaign)
  • Regional assessment based on monitoring datasets (if available)
• Inorganics/ Metal specific adaptations:
  • Current version of EUSES (or Chesar) is not suitable to estimate concentrations in crops, meat and milk as transfer models are based on Kow.
  • Instead, duplicate diet studies, total diet studies or market basket studies will be used to address the uptake of metals via food.
  • Drinking water, and inhalation can be addressed via EUSES.

Task Force, Joint submission & Consortia Management

• General consortium management

  Communication and correspondence with consortium members and joint submission members/ LoA buyers, budget planning and monitoring budget compliance, review and payment of incoming invoices, regular updating of cost allocation/ cost itemisation, archiving/ documentation, maintenance of website collaboration with the REACH manager and CEO, liaison to external service provides such as the bank, tax accountant and tax authorities, lawyers, review their work such as tax declaration, annual balances, proof of shareholding. Adaptation of contracts and agreements (with external legal support as applicable). Preparation and leading of annual meetings (online, face-to-face, or hybrid), writing of minutes.

• Cost sharing/ reimbursement exercise

  Regular substance inventory, cost allocation, update calculation files, preparation of invoices to registrants, follow up on payments and inquiries.

• Letter-of-access and Licence to Use management

  Email communication with interested parties prior to the LoA purchase, addressing questions on the procedure, preparation of agreements, invoicing, preparation of data packages, calculation of individual cost shares for single study requests (LtU). May involve communication and collaboration with stakeholders in connection with other REACH-like jurisdictions, including UK REACH, KKDIK etc.

• External representation

  Representing the Consortium in their communication with industry, professional and governmental organisations (notably the European Commission, the European Chemicals Agency, ECHA, and national competent authorities).

• Technical activities

  Organisation of meetings of technical working groups as may be formed from time to time and taking/issuing minutes thereof. Provision of support to technical working groups, lead registrants, etc. Oversight of technical programme development and implementation thereof by consultants, laboratories, etc.

• Task force

  Leading and supporting task forces to address complex regulatory challenges. Expert in coordinating multidisciplinary teams, developing strategic action plans, and providing science-based guidance to ensure compliance and proactive risk management. Skilled in regulatory defence, supporting companies and legal teams in responding to authority actions and defending dossiers with robust scientific evidence. Recognized for bridging technical expertise with regulatory foresight to drive consensus and effective decision-making.

Special Analytics (conducted by sub-contractor)

• Nano
  • Requested characterisation according to REACH, SCCS, EFSA (constituent particle size)
  • Dispersion stability
  • Quantification in biological samples
  • Biological relevant PSD for read across approaches (non-separable particle size)
  • Biological in vitro test systems for read across approaches
    • Potential bioavailability (Transwell assay)
    • Inflammatory potential (Macrophage assay/ROS assay/lung endothelial assay)
    • Potential developmental toxicity (e.g. EST assay)
• Trace analysis
• Spectroscopic methods (NMR, IR, UV, MS, XRD, XRF, EM, …)
• Metal analysis (ICP-MS/OES)

Data Management & Bio-Statistics

Reliable conclusions start with reliable data. We structure, validate, and analyse datasets to uncover patterns that matter — from experimental design to final interpretation. Our biostatistical expertise includes resampling, trend and dose–response modelling, and uncertainty quantification, all within transparent and reproducible workflows.

Tailored Online Surveys

Complex regulatory questions often require solid, real-world data. We design and conduct online surveys that capture substance uses, workplace exposure information, and material specifications across Europe. From translating scientific questions into clear survey logic to follow-up on responses, evaluation, and interpretation, we manage the entire process. The outcome: robust, transparent data that strengthen regulatory submissions and risk assessments.

Tool Development

We develop industry-grade tools for the chemical sector—for example, exposure-estimation engines, demonstrators that document compliance with strictly controlled conditions, and cost-to-target planners that quantify the effort needed to reach limit values. Depending on the use case, we deliver solutions in Excel, as stand alone applications or as modern web apps. Combining scientific scope, statistics, and software engineering, we turn ideas into validated prototypes and then into robust, well-documented products — fast, reliable, and ready for real-world decisions.

Further Scientific & Regulatory Support

• Socio-economic analysis & impact assessment

  Regulatory decisions require a balance of evidence, context, and communication. We provide scientific support throughout decision-making processes — from socio-economic analyses and impact assessments of potential regulatory measures to substance classification and the derivation of occupational limit values.

  Our work includes evaluating the economic and technical feasibility of proposed actions, helping to ensure that science-based decisions remain both effective and proportionate. We bridge data and policy, translating complex evidence into arguments regulators can trust.

• QSAR calculation
  • Use approved QSAR models and other valid and suitable tools to comprehensively screen and analyse physicochemical, ecotoxicological, and toxicological aspects and endpoints and to address dossier gaps in compliance with regulatory requirements (e.g., REACH, EFSA)
  • Comprehensive documentation for regulatory purposes (OECD)
  • Considering available methods, specified parameters and metabolic pathways to strengthen the overall picture when assessing substances in terms of potential risks
  • Selection of tools/applications: OECD/ECHA QSAR Toolbox; US EPA EPI Suite; PBT Profiler; TOXTREE
• Publication in scientific journals
• Training courses
• Support in legislative processes
  • Authorisation
  • Restriction
  • OEL setting (EU & national)
• Guidance development